| Move hand | Mouse | ||
| Shoot | Left mouse button | ||
| Jump / Up | W | ||
| Left | A | ||
| Down | S | Only works once the Down To Earth Powerup has been selected. | |
| Right | D | ||
| Bullet-time | Q or Right mouse button | ||
| Switch gun | E or Mouse wheel | ||
| Drop gun | F or Middle mouse button | ||
| Jetpack | Shift | ||
| Pause | P | ||
| Go to menu | Enter | ||
| Quit game | Escape |
| Willis | Invincibility | |
| NewYorkMinute | Infinite Bullet Time | |
| Guide | Laser Sight | |
| Armstrong | 2x Reach | |
| Apollo | All enemies use explosives | |
| FLCL | Infinite Ammo | |
| Hop | Higher Jump | |
| Gump | 2x Speed | |
| Minnie | Spawn with Minigun | |
| Arnold | 4x Strength |